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[12] Gastric acid-suppressing agents (proton-pump inhibitors and H-receptor antagonists) diminish dietary B12 liberation from protein complexes, a pharmacodynamic interaction that can exacerbate underlying deficiency
[17] Physiologic B12 requirements increase during gestation, and parenteral cyanocobalamin is considered appropriate when dietary intake or intestinal absorption is inadequate
Downstream observations in models include transcriptional changes consistent with enhanced mitochondrial function and lipid utilization
Older Adults: Age-related declines in B12 absorption can impact cognitive and physical health, and injections help support overall well-being
If you are very B12 deficient you will notice an increase in energy and a reduction in symptoms of tingling, numbness, or twitching/zaps within 24 hours
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