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Abbreviations: AM (alveolar macrophage), BAL (bronchoalveolar lavage), DC (dendritic cell), e-cig (e-cigarette), e-cig vaped extract (EVE), gen (generation), h (hour), min (minute), NK (natural killer), PG (propylene glycol), THC (tetrahydrocannabinol), VG (vegetable glycerin) There is limited knowledge of the effect of e-cigarettes on B cells, however, mouse models have demonstrated alterations in mucosal and serum antibody titers, as well as modified responses to infectious challenges (Figure 6)