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Clinical outcome was defined as death in 7 studies [12, 16, 26, 33, 34, 45, 54], intensive care unit (ICU) admission or requirement of mechanical ventilation in 6 studies [8, 10, 15, 17, 21, 23], prolonged viral shredding in 2 studies [43, 44], severe or critical (respiratory distress with respiratory rate 30/min, or oxygen saturation 93% at rest, or oxygenation index 300 mmHg, based on the diagnostic and treatment guideline for SARS-CoV-2 issued by Chinese National Health Committee [55] or the American Thoracic Society guidelines [56] for community acquired pneumonia) in 18 studies, the primary composite end point (ICU admission, the use of mechanical ventilation, or death) in 2 studies [18, 47], abnormal chest imaging in 1 study [52], acute cardiac injury in 1 study [19], progression of disease to more severe status (including increasing oxygen supplement, pneumonia exacerbation, transferred to ICU, and sepsis) in 10 studies [13, 20, 24, 25, 30, 32, 34, 37, 38, 48]
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