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Neelakantan and colleagues (Biochem Pharmacol, 2017) then took the pharmacological step, reporting that selective, membrane-permeable small-molecule NNMT inhibitors reversed high-fat-diet-induced obesity in mice this is the study most directly relevant to the 5-Amino-1MQ class, because it moves from the target matters to a drug against the target does something in a live animal. And again, it is a mouse study

However, B12 does not expire in the same sense milk does

It mimics GH's lipolytic effects, promoting fat breakdown and inhibiting new fat formation, while early research suggests it preferentially acts on adipose tissue without significantly affecting IGF-1 or systemic GH levels

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If you experience side effects that concern you, discuss them with your GP or practice nurse