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The Table 1 provides a brief overview of the impact of hormonal imbalances on oxidative stress, with a focus on glucocorticoids, mineralocorticoids, and androgens

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Main methods Assessment included magnesium sulfate (560 mg/kg intraperitoneally)-induced muscle weakness, muscle and brain lesions, hypermagnesemia, hyperkalaemia, increased serum enzyme values assessed in rats during and at the end of a 30-min period and medication (given intraperitoneally/kg at 15 min before magnesium) [BPC 157 (10 g, 10 ng), l-NAME (5 mg), l-arginine (100 mg), alone and/or together]

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In some embodiments, the otic composition or formulation comprises less than 1% by weight of C1-C6 alcohols or C1-C6 glycols