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These included investigating the production of synthetic tobacco, increasing nicotine levels in low-tar cigarettes to compensate for any loss of nicotine in the process of reducing tar, and selective filtration of the most toxic substances in cigarette smoke, such as carbon monoxide

Elevated COX-2 promotes inflammation and prostaglandin synthesis, while VEGF stimulates angiogenesis, both facilitating tumor growth and metastasis

In: Katazung's Basic and Clinical Pharmacology

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