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To detect dopamine and serotonin concentrations, the coulometric detector (CoulArray model 5600A, ESA, Inc)

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Patients with elevated plasma B12 ( 1000 ng/L) at first measurement (n = 344) were matched for age and sex with patients having 2 normal B12 measurements ( 800 pmol/L (1084 ng/L) was associated with a diagnosis of cancer in the following year with a Standardized Incidence Ratio of 6.3 [95% CI 5.76.9] in a Danish cohort 16 , and a B12 between 800 and 1000 pmol/L (10841355 ng/L) was associated with an Incidence Rate Ratio of 2.9 [95% CI 2.43.5] in a British cohort 17

The primary outcome measure is frequency of HDDs (at least five standard drinks per day for men and at least four for women), which is a sensitive clinically relevant measure for alcohol trials [47]

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