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In general, the GSH/GSSG ratio is greater than 10 for cells and organelles like mitochondria and nuclei, whereas the endoplasmic reticulum has a lower GSH/GSSG ratio between 1 and 3 [14]

[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Cheleschi S, Fioravanti A, de Palma A, Corallo C, Franci D, Volpi N, et al

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These results suggested that the HPA axis may be stimulated by increased inflammatory signaling and T-cell activation in MDD, which could subsequently result in immunosuppressive effects, as detected by the LPA test [14]