Maki et al., in a randomized, double-blind, placebo-controlled multicenter clinical trial involving 373 women with a recent history of UTIs consuming 240 mL of cranberry beverage per day, reported a 40% reduction in the incidence of UTIs compared to the placebo with one clinical UTI event prevented for every 3.2 women [78]
Oncogene 19(49):56145619 Dong Y et al (2009) Downregulation of EphA1 in colorectal carcinomas correlates with invasion and metastasis
Clinical trial design must account for this heterogeneity, possibly incorporating patient stratification based on imaging, genetic risk factors (e.g., APOE or TREM2 variants), or peripheral cytokine profiles
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the cells from tumor and draining lymph nodes tissue were stained with anti-CD11c-PE, anti-CD80-FITC, and anti-CD86-APC antibodies for 30 min, and further analyzed the ratio of mature dendritic cells (DCs)