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22:56396 doi: 10.1038/s41423-025-01284-9 77 VlahosR

Unlike AALI mice, the necrotic cells persisted in the liver at 72 hours, suggesting that the mechanisms driving dead cell clearance were impaired ( Figure 1B ) ( Figure 1 Reduced numbers of myeloid cells in the livers of mice with AALF Because myeloid cells clear dead cell debris from the APAP-injured liver ( hi monocytes and Kupffer cells ( + myeloid cells accumulate in the livers of patients with APAP-induced ALF ( + myeloid cells were present in the liver and more concentrated near centrilobular regions where liver injury occurred ( Figure 2A , CD68 staining appears red