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The safety of the molecule administrated in mice models comparing to other senolytic treatments 23 push to start more clinical studies in various pathologies (Table 1)

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[17] The importance of lysyl oxidase-derived cross-linking was established from animal studies in which lysyl oxidase was inhibited either by nutritional copper-deficiency or by supplementation of diets with -aminopropionitrile (BAPN), an inhibitor of lysyl oxidase