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The MTR gene works in the final step to regenerate homocysteine into methionine using methyl-B12 (methylcobalamin) MTRR regenerates the methylcobalamin for MTR to use again.[ref] Both are a vital part of the methylation cycle

The initial management of overdose: After a careful clinical evaluation of the patient the importance of time elapsed since last ingestion or administration, the amount of poison swallowed and discarding the contraindication of certain procedures, the professional will decide whether or not the treatment of general rescue: emesis or gastric lavage, activated charcoal and saline purgative (45 to 60 minutes after the activated carbon), hemodialysis