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Metabolism-based targets exert a very low variability and are predictably essential for viral replication, resulting in a high resistance barrier and a predictable broad antiviral activity

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305 At the therapeutic level, therapeutic vaccines targeting Arg 1 have been shown to activate antitumor immunity in a variety of syngeneic mouse tumor models such as lung cancer, melanoma, and colon cancer, and the combination of Arg 1 vaccine with anti-PD-1 antibody can increase T cell infiltration, inhibit myeloid cell function, and increase the ratio of tumor-infiltrating M1/M2 macrophages

Humphry, G

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