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Besides, the treatment of berberine can reduce the activity of ecto-nucleoside triphosphate diphosphohydrolase (NTPDases) and 5-nucleotidasein the cerebral cortex and hippocampus (de Oliveira et al., 2019)

Detection frequency: once every 3 months in the initial stage and once every 6 months in the later stage

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Genetic testing is also available for breeds that are prone to inherited selective cobalamin malabsorption