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Eur J Public Health 9:631637 Hoek J, Gendall P, Gifford H, Pirikahu G, McCool J, Pene G, Edwards R, Thomson G (2012) Tobacco branding, plain packaging, pictorial warnings, and symbolic consumption

We also observed a trend of increased gene expression of involucrin and TG1 which correlated with their elevated protein levels in the epidermis of smokers, although these results did not reach statistical significance

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Regardless, he writes in the study that big tobacco historically "purchased the best research minds to help them understand the mind of the consumer." Cigarettes, needless to say, are horrifyingly bad for your health.