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In terms of adverse drug reactions, aggregated data from phase II and III studies indicate that while dotinurad can potentially cause liver-related adverse reactions, such as hepatic steatosis and abnormal liver function tests, which the incidence is lower compared to benzbromarone

Wang J, Peng M, Oyang L, Shen M, Li S, Jiang X, et al

R., Tye-Din, J., Muckenthaler, M

In some instances, the practical osmolarity of a formulation described herein is measured by vapor pressure osmometry (e.g., vapor pressure depression method) that allows for determination of the osmolarity of a formulation at higher temperatures

Noonin C, Thongboonkerd V