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Foundational NNMT Discoveries The foundational research establishing NNMT as a metabolic regulator and potential therapeutic target came from studies by Daniel Kraus and colleagues published in Nature in 2014, which demonstrated that NNMT expression is dramatically upregulated in adipose tissue of obese humans and diet-induced obese mice, and that genetic knockdown of NNMT in mice protected against diet-induced obesity and improved metabolic parameters

Elevated liver enzymes usually indicate inflammation or injury of the liver

This leads to a lower red blood cell count and iron deficiency

In any case, the physician must do a complete diagnostic workup to track down the reason for elevated vitamin B12 levels

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