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To summarize, these validations showed that the expression patterns of the detected BRGs are replicated in independent datasets (UKBEC and GTEx) and indeed showed progressively disturbed patterns in iLBD and PD patients (PD microarray and PD RNA-seq datasets)

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Linden 2008

Currently used in vitro assays do not adequately predict in vivo observed effects, predominantly due to an inadequate preservation of the organs microenvironment in the models applied

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