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Ethics statement The studies involving human participants were reviewed and approved by the Human Research Ethics Committee of the Faculty of Health Sciences of the University of Cape Town (HREC UCT REF 248/2014), the Human Research Ethics Committee of the Faculty of Health Sciences of Stellenbosch University (REF 248/2014), the Institutional Review Board at Childrens Hospital in Los Angeles (CHLA-19-00228), and the Institutional Review Board at the University of California, Irvine (UCI #212354)

Will reduced-nicotine cigarettes make it safe to smoke

A good quality Hepa filter ( filtering to 0.1 micron if possible, but filtering to not 0.3 will still suffice ) 2

The American is the first 100% all-American cigar

Both his parents are long-time smokers, although his mom has switched to vaping