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Supporting the above, DCA can delay the onset and reduce the progression of murine collagen type II (CII)-induced arthritis 57 and moderate the procatabolic effect of IL-1 in bovine chondrocytes 58

A Transwell system (mimics the physiological barrier between two cellular compartments) was utilized to evaluate the permeability across BBB in an in vitro model utilizing brain capillary endothelial cells (BCECs)