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These involve increased acetylcholinesterase concentration in the prefrontal cortex, hippocampus, and striatum (21, 89, 91)

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Biological biomolecules based on gene expression, epigenetic alterations, microRNA profiles, protein phosphorylation and cytokine signatures can contribute to the selection of subsets of these patients for specific natural agents, monitoring in vivo biological efficacy and potential synergistic (or antagonistic) interactions with medical therapies (223)

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