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Through the interaction of these intermediates, exposure to tobacco smoke can directly or indirectly cause the formation of DNA and protein adducts, mutations, chromosomal abnormalities, micronucleus formation, sister chromatid exchange (SCE), and promoter methylation (Fig

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Cigarettes and smokeless tobacco can be shipped under these conditions: Intra-Hawaiian shipments and Intra-Alaskan shipments Business purposes Individual small quantity or as a gift As a return shipment to the manufacturer All shipments must be approved by the Postal employee at the post office to verify that the recipient is of the legal age