As the key regulator of ferroptosis and oncogene, GPX4 is thus a promising therapeutical target in cancer therapy
X., Liu, J
Frontiers in pharmacology , 11 , 579944
Abbreviations 1 O 2 : Singlet oxygen ADP: Adenosine diphosphate AOX: Alternative oxidase APX: Ascorbate peroxidase Asc: Ascorbate ATP: Adenosine triphosphate cat : Catalase knockout CAT: Catalase chl- E : GSH Chl-roGFP oxidation state chl-roGFP2: Chloroplast targeted roGFP CLSM: Confocal-laser scanning microscopy cry: Cryptochrome DTT: Dithiotreitol E : h Reduction potential ER: Endoplasmic reticulum FIN219: Far-Red Insensitive 219 FIP1: FIN219-interacting protein 1 GGT-1: Gamma-glutamyl transferase/transpeptidase 1 ggt : GGT-1 knockout GR: Glutathione reductase GSH: Reduced glutathione GSHS: Glutathione synthetase GSSG: Oxidized glutathione (= glutathione disulfide) GSSG/GSH: Reduction state of glutathione GT: Glutathione transferase H 2 O 2 : Hydrogen peroxide HPLC: High performance liquid chromatography HyPer2: Fluorescent H 2 O 2 biosensor IgG: Immunoglobulin G immunolabeling: Total glutathione localization by use of a specific antibody LEDs: Light-emitting diodes mbrB: Monobromobimane mchlB: Monochlorobimane NADP + : Nicotinamide adenine dinucleotide phosphate NADPH: Reduced form of NADP + NEM: N-ethylmaleimide O 2 : Superoxide radicals pad : Phytoalexin deficient phyA: Phytochrome A PS II: Photosystem II roGFP: Redox-sensitive green fluorescence protein ROS: Reactive oxygen species SOD: Superoxide dismutase TEM: Transmission electron microscope Total glutathione: Sum of reduced (GSH) and oxidized (GSSG) glutathione, detected via immuno-labeling vtc : Vitamin C1 gene -EC: -Glutamylcysteine -ECS: -Glutamylcysteine synthetase References Appolloni E, Pennisi G, Zauli I, Carotti L, Paucek I, Quaini S, Orsini F, Gianquinto G (2022) Beyond vegetables: effects of indoor LED light on specialized metabolite biosynthesis in medicinal and aromatic plants, edible flowers, and microgreens
Gth L, Nagy T, Ksa Z, et al
