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Regarding MMP-2, previous reports by others have shown how ROS regulate the activity of vascular matrix metalloproteinases in vitro including MMP-2 and MMP-9 [50] which have an implication in atherosclerotic plaque stability

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However, long-term caffeine tolerance and reduced benefit may occur over time

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It can cause cataract symptoms, like cloudy vision and even blindness, if left untreated