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In Machine yield cigarettes , smoke constituents or chemical classes could not be entirely eliminated from mainstream smoke NFDPM (Nicotine-Free Dry Particulate Matter), nicotine and CO and glycerol

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eLife 4:e09623 Pratte P, Cosandey S, Goujon Ginglinger C (2017) Investigation of solid particles in the mainstream aerosol of the tobacco heating system THS2.2 and mainstream smoke of a 3R4F reference cigarette

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Lung, throat, stomach, liver, colon, pancreas, and kidney cancers were among those included, along with leukemia