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vBrood was run to replace the piperazine portion of the molecule using the default settings in vBrood

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doi: 10.3389/fendo.2024.1461171 45 TanMYinYMaXZhangJPanWTanMet al

In this framework, endothelial insulin signaling becomes selectively imbalanced: the PI3K/Akt metabolic/vasodilatory arm is suppressed, whereas SHC/MAPK signalingincluding SHC/MAPK-driven ET-1 inductionis relatively preserved or enhanced [1007]