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However, observations suggest that in the brains of AD patients, increased angiogenesis may disrupt this negative feedback loop, leading to an imbalance between angiogenesis and vascular inhibition

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From a biological perspective, ferroptosis is characterized by elevated ROS levels, iron accumulation, mitogen-activated protein kinase (MAPK) activation, decreased cysteine uptake, and glutathione (GSH) depletion [108, 109]

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