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Standard insulin syringes measure in 0.01mL increments (1 unit = 0.01mL), which sets a practical lower limit: concentrations below 100mcg/mL require drawing volumes under 0.05mL (5 units) for typical 2050mcg research doses, introducing significant measurement error

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While this idea is somewhat simplified, its intriguing His hypothesis suggests that the sudden influx of B12 can kickstart repair processes, and if there has been long-standing damage, the rapid onset of these processes might overwhelm the system, causing a temporary worsening of symptoms