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I generally take a magnesium/potassium combo supplement, along with folate (400 to 800 mg a day) , and vitamin D
(2020) published a validated detection assay specific to LongR3-IGF-I, Des(1-3)-IGF-I, and R3-IGF-I in athlete samples
[1] Those who cannot digest or absorb B12 as a result of inherited genetics or damage to the stomach and small intestine require more than can be absorbed from sublingual supplementation
Some people can have symptoms and also seem to have normal levels of these vitamins