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Normally, alveolar epithelial and vascular endothelial cells form a semipermeable interface, which preserves the homeostasis of pulmonary microcirculation and maintains alveolarcapillary interaction 8,22

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There have been reports of hypersensitivity reactions, including angioedema [see Warnings and Precautions (5.7)]

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Some nicotine can also reach the gastrointestinal tract if the saliva is swallowed