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NNMTi treatment combined with lean diet substitution accelerated improved body weight fat loss, increased whole-body lean mass to body weight ratio, reduced liver epididymal white adipose tissue weights, decreased liver adiposity, improved hepatic steatosis, relative to a lean diet substitution alone

Unlike other treatments such as semaglutide and tirzepatide, which act on only one or two receptors, Retatrutide is a triple receptor agonist

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