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GCGR: the negative control Glucagon is on the chart only to be ruled out

In individuals with haemochromatosis, osteoporosis is linked to iron overload (129), and ferroptosis might be the primary factor driving osteoporosis in these populations (130)

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These data are consistent with a clear pro-fibrotic paracrine signal originating from the injured, ballooned hepatocyte

This was accompanied by upregulation of inducible nitric oxide synthase (iNOS), IL-1, and TNF-, and downregulation of arginase 1 (Arg-1), IL-10, and transforming growth factor-beta (TGF-)