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Alcohol (Ethanol) also acts as substrate for CYP2 and inhibits the metabolism of other substrates in the enzyme by binding it to the active site (see Chien, Thummel, and Slattery 1997

Zinc is transported between organelles and the cytoplasm through transport proteins in the SLC39 family (ZIP) or the SLC30 family (ZNT)

Ascorbate stimulates dietary iron absorption, contributes to plasma transferrin-bound iron uptake following binding of the transferrin-iron complexes to the plasma membrane transferrin receptor, stimulates the synthesis of the iron storage protein ferritin, inhibits lysosomal ferritin degradation, and inhibits cellular iron efflux

Notably, all the docked poses demonstrated substantial intermolecular contacts formation with essential residues (His 61 , His 85 , His 94 , His 259 , and His 263 ) and binuclear copper active site in the mh-Tyr enzyme (Table S1, Fig

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