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In the control group, hydrogen was detected abundantly in the intestinal tract, except in the cecum, where very slight amounts were detected (Fig

Kinetic measurements were performed using a UV-2700 spectrophotometer

These observations suggest a significant contribution of CYPOR to NFT-induced Nrf2 activation in the HepG2 model, but also indicate that other cellular flavoprotein reductases are likely to be involved in the formation of the NFT radical anion and its subsequent activation of Nrf2 and synthesis of GCLC and glutathione

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