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The dermatosparaxis ( ADAMTS2 ) [61], cardiac-valvular ( COL1A2 ) [62,63,64], kyphoscoliotic ( PLOD1 , FKBP14 ) [65, 66], and arthrochalasia ( COL1A1 , COL1A2 ) [67, 68] EDS subtypes, also sharing with cEDS several cutaneous and articular issues, are mostly distinguishable for the presence of specific hallmarks [1, 9, 16]

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