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It has been shown that perilesional melanocytes have a lower ratio of Bcl-2/Bax than control melanocytes, suggesting that melanocytes from patients with vitiligo are more susceptible to apoptosis activation due to altered Bcl-2 and Bax expression and that the balance between pro-apoptotic and anti-apoptotic proteins in vitiligo melanocytes is shifted towards apoptosis [44]

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