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The following parameters were used: single voxel p = 0.005, cluster size = 27 voxels (729 mm 3 ), FWHM = 6 mm, cluster connection radius r = 5 mm

*Correspondence: Prue Talbot, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Exposure to antagonists for a particular neurotransmitter can increase the number of receptors for that neurotransmitter or the receptors themselves may become more responsive to neurotransmitters

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