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Mechanism: Four Pathways, One Stack Each pathway maps to different receptors and partially distinct brain regions

Peroxynitrite is believed to inhibit electron flow at CI, CIII, and minimally at CIV via direct interaction with the complexes ( Furthermore, increased free radical production can also induce cell death via the downstream effects of oxidative damage to the respiratory chain and RNS-mediated induction of diminished mitochondrial permeability transition ( Alternatively, RNS-mediated induction of mitochondrial permeability transition may also signal (necrotic or apoptotic) cell death ( There is no doubt that NO plays a key role in the redox state

By screening in four different media conditions, we uncovered their metabolic regulation, including the fitness defects in the mitochondrial folate transporter SLC25A32 KO cells that can be buffered in galactose condition due to substrate limitation in de novo purine biosynthesis

(PubMed) Jacobs C, Hutton B, Ng T, Shorr R, Clemons M