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We propose the concept that aberrant DC activation forms the basis for the deviation of the lung's default tolerogenic response toward allergic inflammation when harmless antigens are concomittantly inhaled with tobacco smoke

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Uric acid (UA), a metabolic derivate of purine nucleotides, is not only a main determinant for gout but is also related to several chronic diseases such as atherosclerosis, metabolic syndrome, chronic kidney disease, and hypertension [911]