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Pulmonary surfactant plays a central role in acute and chronic lung disease (80)

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For example, for a smoking article having a demi slim-sized tobacco rod, a reduced proportion of the smoke stream is in proximity to the outer wrapper of the smoking article than would be the case with a super-slim tobacco rod (circumference approximately 17mm), due to the reduced surface-area to volume ratio of the interior of the cigarette through which the smoke stream passes