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We identified 22 Cochrane systematic reviews on behavioural interventions, pharmacotherapies, combined behavioural and pharmacotherapy interventions, and other interventions.22 We updated our search in June 2024, and findings on benefits and harms were consistent with results from earlier searches (Appendix 2, available at www.cmaj.ca/lookup/doi/10.1503/cmaj.241584/tab-related-content)

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The decision follows a review of the extensive scientific evidence package PMI submitted to the FDA in December 2016 to support its MRTP applications