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The body is undergoing metabolic shifts as fat oxidation increases

In addition, angiotensin II activates NADPH oxidase in the lung, resulting in elevated levels of reactive oxygen species

The nonclassical pyroptosis pathway is mediated by caspase-4/5/11

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Thus glutathione is perhaps uniquely positioned to not only provide cellular protection against oxidative and xenobiotic stress, but to also directly regulate cellular activity, including cell cycle control and induction of apoptosis in overly damaged cells