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keloid fibroblasts were prone to senescence following an ischemic stimulus, and FOXO4-DRI selectively induced the apoptosis of keloid senescent fibroblasts via p53-pS15 translocation from the nucleus to the cytoplasm

If you suspect degradation, starting a fresh vial is the safest approach

Journal of Orthopaedic Research, 21 (5), 976983

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