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In the study's "pessimistic" model, the researchers assumed that fewer people gave up smoking than are doing so under the current rate and that the health risks of e-cigarettes turned out to be worse than scientists' current understanding

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FeNO is an essential marker of eosinophilic airway inflammation, and reduction in its levels may be due to rapid conversion of nitric oxide to peroxynitrite by reactive oxygen and nitrogen species or downregulation of nitric oxide synthase [113, 114]

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