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On the other hand, the endogenous origin of alkanes in exhaled breath is under debate, as they can also derive from exogenous sources 66

Increased oxidative stress plays an important role in airway inflammation 12 and is often linked to enhanced ROS (reactive oxygen species) production or malfunction of antioxidant defenses 13,14

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The PPPs integration with CRC metabolism is exemplified through cysteine metabolism, a glutathione synthesis prerequisite requiring substantial NADPH from PPP-mediated cystine-to-cysteine conversion

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