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Damage to the gums and oral tissues : Using strong dipping tobacco products typically involves prolonged contact between them and the gums, causing irritation, recession, and lesions

Kotoulas SC, Pataka A, Domvri K, Spyratos D, Katsaounou P, Porpodis K, Fouka E, Markopoulou A, Passa-Fekete K, Grigoriou I, et al

One methodological issue that might explain why so few studies have directly examined this important question pertains to the need for relatively large sample sizes to be adequately powered for interaction, or moderation, analyses