Freebase nicotine is the most concentrated type of nicotine found in e-liquids
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Notably, reduction of e-cigarette use for 2 weeks restored levels of some cytokines, suggesting that e-cigarette induced changes may be reversible, while other cytokines remain impaired after reduced e-cigarette used, suggesting that some effects may be more permanent (134)
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(The chemicals in e-cigarettes are considered maybe safer.) At the same time, a person who is addicted to nicotine can smoke for years or even decades before developing a serious illness, while someone who smokes for a short period may experience severe health effects even after just a year
