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This design intentionally slows the onset and smooths the effect curve compared with some other stimulant medications, helping reduce the rush that can feed misuse

Andre Utter (1886-1948) a French painter

The risks of cigarette smoking are related to the amount of smoke inhaled and the duration (years, decades) of exposure, and the death toll from cigarette smoking is appalling

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Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers