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Although extensive studies on the effects of exogenous GSH have been performed, results on the stress responses were still differential across different studies, particularly the variable response of the antioxidant enzymatic activities, where some studies reported a decrease in enzymatic activities albeit an increase in GSH/GSSG ratio (Goodarzi et al., 2020)

Combining peptides with different solubility profiles can lead to clumping, improper dosing, or reduced absorption

A positive FRAT result may raise the question of leucovorin treatment

Ionizing radiation from radiation therapy also induced HIF-1 accumulation, which resulted in nuclear translocation of SLC7A11 and inhibited ferroptosis in HCC (138)

Organic toxins such as pesticides and solvents have also been associated with acute kidney injury and CKD (Pozzi 1985