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The reduced incretin effect of GIP in diabetic subjects may be due to the down-regulation of GIP receptor expression, which has been found in pancreatic islets of diabetic Zucker rats and reverted following correction of hyperglycemia [35]

Campbell et al

Acknowledgments The authors thank the study participants, the investigators and study site staff who conducted the study

The FDA label also explicitly states it is not indicated for weight loss management and notes that long-term cardiovascular safety has not been established